ACADM — Acyl-CoA dehydrogenase medium chain
ACADM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACADM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6, ISCA2 +24 more | |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | AURKAIP1, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1, G3BP1 +19 more | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D, EIF4EBP1 +29 more | View in SCUBA |
About the gene
| Synonyms | ACAD1, MCAD, MCADH |
|---|---|
| Chromosome | 1: 75724431-75787575 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.