DPT — Dermatopontin
DPT belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, ANGPTL7, C7, CHRDL1, GDF6, GPNMB, HAND2, JAM2 +9 more | View in SCUBA |
About the gene
| Chromosome | 1: 168695468-168729206 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.