CHRDL1 — Chordin like 1
CHRDL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHRDL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, ANGPTL7, C7, DPT, GDF6, GPNMB, HAND2, JAM2 +9 more | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2, LAMB2 +8 more | View in SCUBA |
| Smooth muscle cells | BMP-antagonist Niche Development | AP1S2, ARL4C, C3, CCBE1, CD74, CISD1, GREM1, GREM2 +4 more | View in SCUBA |
About the gene
| Synonyms | CHL, MGC1, NRLN1 |
|---|---|
| Chromosome | X: 110673856-110795819 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis, Osteogenesis |
Function
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.