HAND2 — Heart and neural crest derivatives expressed 2
HAND2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HAND2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, ANGPTL7, C7, CHRDL1, DPT, GDF6, GPNMB, JAM2 +9 more | View in SCUBA |
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, LRRC4C, MAP4K4, PYGL, SEC11C, SLC25A36, TBX3 +2 more | View in SCUBA |
About the gene
| Synonyms | bHLHa26, dHand, Hed, Thing2 |
|---|---|
| Chromosome | 4: 173524969-173530229 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding |
| Biological process | Angiogenesis, Differentiation, Transcription, Transcription regulation |
Function
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior- posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG- 3' (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.