Submucosal Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
DPT (dermatopontin), PRELP, and CHRDL1 are ECM/matrix-associated proteins. GDF6 is a BMP family member. HAND2 and OSR2 are developmental mesenchymal TFs marking deep submucosal fibroblasts. GPNMB is expressed in stromal/macrophage-like cells. C7 (complement C7) and JAM2 (junctional adhesion molecule) add immune and adhesion context. The overall signature resembles a deep-layer submucosal fibroblast with BMP signaling and developmental TF activity.
Genes
ADAMTS19, ANGPTL7, C7, CHRDL1, DPT, GDF6, GPNMB, HAND2, JAM2, KCNN3, NAV3, OSR2, PLCXD3, PRELP, SCN7A, SLITRK3, SRPX, ZFHX4
Most correlated modules
- BMP-antagonizing Fibroblast · correlation 0.85
- Wnt-niche Fibroblast · correlation 0.85
- CD34+ Quiescent Fibroblast · correlation 0.83
- Neural-crest Fibroblast · correlation 0.81
- Inflammation-activated ECM · correlation 0.69
- Homeostatic Stromal Identity · correlation 0.60
- Quiescent Stromal Identity · correlation 0.60
- Subepithelial Fibroblast Identity · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.