ANGPTL7 — Angiopoietin like 7
ANGPTL7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANGPTL7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, C7, CHRDL1, DPT, GDF6, GPNMB, HAND2, JAM2 +9 more | View in SCUBA |
| Glial cells | Neuroprotective Secretory Neroprotection | APCDD1, IGFBP6, LRRTM1, PDLIM2, PRELP, SELENOP, TTR, TXNIP +1 more | View in SCUBA |
About the gene
| Synonyms | AngX, CDT6 |
|---|---|
| Chromosome | 1: 11189355-11195981 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
Function
Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.