C7 — Complement C7

C7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

C7's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Myeloid Contamination Cell contamination	BASP1, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D, DRAM2 +20 more	View in SCUBA
Fibroblasts	Submucosal Fibroblast Developmental	ADAMTS19, ANGPTL7, CHRDL1, DPT, GDF6, GPNMB, HAND2, JAM2 +9 more	View in SCUBA
Smooth muscle cells	Stromal Chemokine Secretion Inflammation	CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924, MAOA +9 more	View in SCUBA

About the gene

Chromosome	5: 40909492-41020216
Predicted location	Secreted
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Biological process	Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Function

Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.