E2F2 — E2F transcription factor 2
E2F2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
E2F2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Multi-lineage Contamination Cell contamination | AZU1, CLU, CYP19A1, ELANE, GM2A, GYPC, ITGB7, MS4A3 +4 more | View in SCUBA |
About the gene
| Synonyms | E2F-2 |
|---|---|
| Chromosome | 1: 23506438-23531233 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.