GYPC — Glycophorin C (Gerbich blood group)

GYPC belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GYPC's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Ras signaling BCR/AP1/NFKb pathway	ANKRD28, CCL5, DOK3, GSTK1, HOPX, HSH2D, ITGAM, MCOLN2 +12 more	View in SCUBA
CD4⁺ T cells	Leukocyte adhesion signaling migration & adhesion	ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more	View in SCUBA
Endothelial	EC Cytoskeletal Scaffold Cytoskeletal	ADD3, ANTXR2, CTSD, EPB41L2, FXYD6, MAP4K2, NRP2, RECK +2 more	View in SCUBA
Fibroblasts	Complement-secreting Fibroblast Immune interaction	ADI1, ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, FTL +9 more	View in SCUBA
Gamma-delta T cells	Anabolic Activation Response Housekeeping	ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Hematopoietic progenitor cells	Erythroid Glycolysis Erythropoietic	CMBL, ENO1, GAPDH, LMO2, LY6E, MAP7, NENF, PKM +3 more
Innate lymphoid cells	mRNA Translation RNA processing & translation	ABHD14B, ARHGDIA, CD2BP2, EEF2, EIF3L, H2AJ, HNRNPA0, HNRNPDL +6 more	View in SCUBA
Lymphatic endothelial	Cytoskeletal Housekeeping Cytoskeletal	ARPC5, C11orf58, CD81, CNBP, DYNLT1, PPP1CA, SYPL1, TMBIM6 +3 more	View in SCUBA
Macrophages	Resident Mac Identity Tissue homeostasis	ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1 +16 more	View in SCUBA
Monocytes	Multi-lineage Contamination Cell contamination	AZU1, CLU, CYP19A1, E2F2, ELANE, GM2A, ITGB7, MS4A3 +4 more	View in SCUBA
Smooth muscle cells	ER Secretory Trafficking Protein processing & ER	ARF4, DEGS1, P4HB, PDIA6, SH3PXD2A, SSR3, TMED9, TMEM123	View in SCUBA

About the gene

Synonyms	CD236, CD236R, Ge, GPC, GYPD
Chromosome	2: 126656133-126696667
Predicted location	Membrane
Essential gene	No
Protein class	Blood group antigen proteins, CD markers, Predicted membrane proteins
Molecular function	Blood group antigen

Function

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.