GM2A — Ganglioside GM2 activator
GM2A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GM2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more | View in SCUBA |
| Monocytes | Multi-lineage Contamination Cell contamination | AZU1, CLU, CYP19A1, E2F2, ELANE, GYPC, ITGB7, MS4A3 +4 more | View in SCUBA |
About the gene
| Synonyms | GM2-AP, GM2AP, SAP-3 |
|---|---|
| Chromosome | 5: 151212150-151270440 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism, Sphingolipid metabolism |
Function
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium- independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D- galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.