ECI1 — Enoyl-CoA delta isomerase 1
ECI1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling activation TCR/AP1/NFKb pathway | CNST, CORO1B, DAPP1, FAAH2, FCMR, GPCPD1, KLHL24, MLLT3 +8 more | View in SCUBA |
| Gamma-delta T cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1D, ATP5F1E, ATP5MC2, ATP5MC3, ATP5MF, ATP5MG, ATP5MK, ATP5PD +23 more |
About the gene
| Synonyms | DCI |
|---|---|
| Chromosome | 16: 2239402-2252300 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Key enzyme of fatty acid beta-oxidation (Probable). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2- trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (By similarity). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.