Oxidative Phosphorylation
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by Complex I subunits: NDUFB10, NDUFS7, NDUFS6, NDUFS8, NDUFB7, NDUFA3. CYC1 (cytochrome c1, Complex III), SAMM50 (mitochondrial outer membrane SAM complex), IDH3B (TCA isocitrate dehydrogenase), SLC25A39 (mitochondrial glutathione carrier), SLC25A11 (oxoglutarate/malate carrier), GOT2 (mitochondrial aspartate aminotransferase), GFM1 (mitochondrial translation elongation factor), CHCHD10 (mitochondrial intermembrane space), ATP5F1D (ATP synthase delta subunit), ECI1 (enoyl-CoA isomerase, beta-oxidation). Core coherence with all genes as core members. This is a second OxPhos module complementary to M99, with stronger emphasis on Complex I and mitochondrial inner membrane organization. Both M99 and M141 are significantly downregulated in inflammation and restored with treatment, confirming the colonocyte metabolic suppression program in IBD.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.93
- Mitochondrial Biogenesis · correlation 0.90
- Crypt Colonocyte Identity · correlation 0.88
- Mitochondrial Biogenesis · correlation 0.87
- Colonocyte HOX Identity · correlation 0.86
- Mitochondrial Membrane Dynamics · correlation 0.86
- Mitochondrial Peroxisomal Metabolism · correlation 0.84
- Colonocyte Differentiation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.