ATP Synthase Complex
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 32 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 32 genes have a known function matching the annotation |
Why this annotation
This is the tightest (core coherence) OxPhos module in the batch. It is dominated by ATP synthase subunits: ATP5MG, ATP5F1E, ATP5MC3, ATP5PO, ATP5MC2, ATP5PF, ATP5F1D, ATP5MK, ATP5PD (Complex V subunits). UQCR11 (Complex III), COX8A (Complex IV), TOMM6 (outer membrane translocase), and SLC25A1 (mitochondrial citrate carrier) round out the mitochondrial program. REX1BD, ELOB, COPS9, SEM1, MZT2B, OST4, FAAP20 are housekeeping/proteasome-related genes. The ATP synthase subunit dominance makes this a clear OxPhos module.
Genes
ATP5F1D, ATP5F1E, ATP5MC2, ATP5MC3, ATP5MF, ATP5MG, ATP5MK, ATP5PD, ATP5PF, ATP5PO, CENPX, COPS9, COX8A, ECI1, ELOB, FAAP20, FAM174C, METTL26, MICOS10, MZT2B, NOP53, OST4, PYURF, RACK1, RBIS, REX1BD, SEM1, SLC25A1, SSR4, TAF10, TOMM6, UQCR11
Most correlated modules
- Mitochondrial Dynamics · correlation 0.88
- RNA Processing · correlation 0.86
- Mitochondrial Biogenesis · correlation 0.83
- Electron Transport Chain · correlation 0.81
- Oxidative Phosphorylation · correlation 0.81
- TCR Vesicular Trafficking · correlation 0.80
- Mitochondrial Housekeeping · correlation 0.78
- NKG2D Cytotoxic Activation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.