ECPAS — Ecm29 proteasome adaptor and scaffold
ECPAS belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECPAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, EPB41L3, FUBP1, GATAD2A, GNA12, LRRFIP2, MED15 +10 more | View in SCUBA |
About the gene
| Synonyms | ECM29, FLJ22036, KIAA0368 |
|---|---|
| Chromosome | 9: 111360685-111484745 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.