Transcriptional Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include GATAD2A (NuRD chromatin remodeling complex), MED15 (Mediator transcriptional coactivator complex), CUX1 (homeodomain TF), ZNF654 (zinc finger TF), TBK1 (innate immune kinase/NF-κB), FUBP1 (transcriptional/post-transcriptional regulator), and LRRFIP2 (innate immune signaling). The module is broadly enriched in mono_mac. Despite weak coherence, the dominant theme across hub genes is transcriptional regulation and signaling machinery. TBK1 and LRRFIP2 add innate immune signaling flavor, but the overall program reflects general transcriptional regulatory activity in monocyte-derived macrophages. No tight single pathway is identifiable; the module likely captures a broad monocyte transcriptional regulatory state.
Genes
CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, GNA12, LRRFIP2, MED15, PHTF1, PITPNB, RAPGEF1, SCFD1, SERTAD2, STK24, TBK1, TP53BP2, ZCCHC2, ZNF654
Most correlated modules
- Endosomal Vesicle Trafficking · correlation 0.97
- Microtubule Organization · correlation 0.96
- Ubiquitin-Proteasome Regulation · correlation 0.96
- NF-κB AP-1 Signaling · correlation 0.96
- Epigenetic Remodeling · correlation 0.95
- Rho GTPase Signaling · correlation 0.94
- Transcriptional Repression · correlation 0.94
- RAB-mediated Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.