GNA12 — G protein subunit alpha 12
GNA12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNA12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, LRRFIP2, MED15 +10 more | View in SCUBA |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, ANKRD9, CXCL16, DNMBP, EPB41L3, GFOD1, GNA13, MRAS +7 more | View in SCUBA |
About the gene
| Synonyms | gep |
|---|---|
| Chromosome | 7: 2728105-2844308 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins |
| Molecular function | Transducer |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.