LRRFIP2 — LRR binding FLII interacting protein 2
LRRFIP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRRFIP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Inflammation | ADI1, APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2 +11 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, B4GALT5, BACH1, CHD2, CNST, DENND5A, HIVEP1, HIVEP2 +11 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, GNA12, MED15 +10 more | View in SCUBA |
About the gene
| Synonyms | HUFI-2 |
|---|---|
| Chromosome | 3: 37052626-37183689 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Biological process | Wnt signaling pathway |
Function
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.