GATAD2A — GATA zinc finger domain containing 2A
GATAD2A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GATAD2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | ASXL1, CHD1, KMT2E, LONRF3, MED13, NUP153, PFKFB3, RYBP +1 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GNA12, LRRFIP2, MED15 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Epigenetic Chromatin Regulation DNA/chromatin regulation | ASXL1, CREBBP, FNIP1, PELI1, PNRC1, RAPGEF1, RYBP, ZCCHC2 +1 more |
About the gene
| Synonyms | p66alpha |
|---|---|
| Chromosome | 19: 19385826-19508932 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.