ECRG4 — ECRG4 augurin precursor
ECRG4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECRG4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Histone Variant Chromatin DNA/chromatin regulation | ATP5MJ, ATP5MK, H2AZ1, H2AZ2, H3-3A, H3-3B, MACROH2A1, MICOS10 +6 more | View in SCUBA |
About the gene
| Synonyms | augurin, C2orf40 |
|---|---|
| Chromosome | 2: 106063246-106078155 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
Function
Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.