MACROH2A1 — MacroH2A.1 histone
MACROH2A1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MACROH2A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, EIF4G2, GARS1 +20 more | View in SCUBA |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | ARF5, C17orf49, DDOST, GNB2, H2AX, H2AZ1, H2AZ2, IFT25 +2 more | View in SCUBA |
| Smooth muscle cells | Histone Variant Chromatin DNA/chromatin regulation | ATP5MJ, ATP5MK, ECRG4, H2AZ1, H2AZ2, H3-3A, H3-3B, MICOS10 +6 more | View in SCUBA |
About the gene
| Synonyms | H2AFY, macroH2A1.2 |
|---|---|
| Chromosome | 5: 135334381-135399914 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (By similarity). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3. In contrast to isoform 1, does not bind poly- ADP-ribose. Represses SOD3 gene expression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.