H3-3A — H3.3 histone A
H3-3A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H3-3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | High-abundance housekeeping Housekeeping | ARPC3, CD63, CYSTM1, DYNLL1, EIF1, EPCAM, H3-3B, S100A10 +1 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3 +19 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
| Natural Killer cells | Mitochondrial Membrane Organization Mitochondrial & OxPhos | ATP5MJ, ATP5MK, BBLN, CIAO2B, GABARAP, MICOS10, PHB1, SEPTIN7 +1 more | View in SCUBA |
| Neutrophils | Neutrophil Survival Program Inflammatory | B2M, BCL2A1, CEBPB, EIF1, FTH1, FTL, H3-3B, PNRC1 +2 more | |
| Smooth muscle cells | Histone Variant Chromatin DNA/chromatin regulation | ATP5MJ, ATP5MK, ECRG4, H2AZ1, H2AZ2, H3-3B, MACROH2A1, MICOS10 +6 more | View in SCUBA |
About the gene
| Synonyms | H3.3A, H3F3, H3F3A |
|---|---|
| Chromosome | 1: 226061851-226072019 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.