Histone Variant Chromatin
Gene co-expression module in Smooth muscle cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Dominated by replication-independent/variant histones (H3-3A, H3-3B, H2AZ1, H2AZ2, MACROH2A1) together with S-phase enzymes TK1 and RAD51AP1, indicating chromatin assembly/nucleosome variant exchange in cycling cells. Septins (SEPTIN2/7) and a few small mito/ribosome genes are peripheral, sparsely detected passengers. Very low detection (1.9%) fits a rare cycling subpopulation. Neighborhood context (M87 mitotic, M51 cytokinesis, M65 proliferative housekeeping) confirms this is the chromatin arm of the same proliferative program.
Genes
ATP5MJ, ATP5MK, ECRG4, H2AZ1, H2AZ2, H3-3A, H3-3B, MACROH2A1, MICOS10, RAD51AP1, RBIS, SEPTIN2, SEPTIN7, TK1, WIF1
Most correlated modules
- Mitotic Spindle · correlation 0.91
- Anaphase Cytokinesis · correlation 0.89
- Microfibrillar ECM Program · correlation 0.73
- Proliferative Biosynthesis · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.