ENTREP1 — Endosomal transmembrane epsin interactor 1
ENTREP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENTREP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Endothelial Receptor Signaling endothelial development | ADGRF5, ART4, FLRT2, P3H2, PDGFC, PLSCR4, SNCAIP, SRGAP3 +2 more | View in SCUBA |
About the gene
| Synonyms | C9orf61, ENTREP, FAM189A2, X123 |
|---|---|
| Chromosome | 9: 69324567-69392558 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.