SCUBA

ADGRF5 — Adhesion G protein-coupled receptor F5

ADGRF5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ADGRF5's module in each cell type

Cell typeModuleShares the module with
EndothelialEndothelial Junction Identity
Endothelial cell development		AKAP13, CDH5, CXCL12, DENND5A, FGF12, FURIN, HSPA12B, NES +13 moreView in SCUBA
FibroblastsICC niche interactaion
Gut motility		ABCC9, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX, HRH2 +10 moreView in SCUBA
Lymphatic endothelialEndothelial Receptor Signaling
endothelial development		ART4, ENTREP1, FLRT2, P3H2, PDGFC, PLSCR4, SNCAIP, SRGAP3 +2 moreView in SCUBA

About the gene

SynonymsDKFZp564O1923, GPR116, KIAA0758
Chromosome6: 46852522-46954943
Predicted locationMembrane
Essential geneNo
Protein classG-protein coupled receptors, Plasma proteins, Predicted membrane proteins
Molecular functionG-protein coupled receptor, Receptor, Transducer

Function

Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump (By similarity). As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.