Lymphatic endothelial: gene co-expression modules
Endothelium of lymphatic capillaries and collectors; they drain interstitial fluid, absorb lipids, and guide dendritic cells and lymphocytes toward draining lymph nodes via chemokine gradients.
SCUBA's reference network for Lymphatic endothelial holds 96 gene modules covering 1,240 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Lymphatic endothelial network in SCUBA
Cytoskeletal (10)
- Actin Cytoskeletal Dynamics · 8 genes
- Actin Cytoskeletal Scaffold · 10 genes
- Actin-based Migration · 9 genes
- Actomyosin Contractility · 15 genes
- Actomyosin Cytoskeleton · 17 genes
- Caveolae Cytoskeletal · 16 genes
- Cilia Centrosome Program · 16 genes
- Cytoskeletal Housekeeping · 12 genes
- Rho/Ras GTPase Regulation · 13 genes
- Septin Cytoskeleton · 10 genes
DNA/chromatin regulation (5)
- Chromatin Remodeling · 10 genes
- Chromatin Remodeling · 13 genes
- Chromatin Remodeling · 11 genes
- DNA Damage Apoptosis · 13 genes
- DNA Damage Response · 16 genes
endothelial development (12)
- Anticoagulant Barrier · 9 genes
- Endothelial Identity · 13 genes
- Endothelial Identity · 11 genes
- Endothelial Receptor Signaling · 11 genes
- Hippo-mTOR Quiescence · 8 genes
- Lymphangiogenesis ECM · 19 genes
- Lymphatic EC Identity · 11 genes
- Lymphatic Specification · 18 genes
- Lymphatic Vascular Stability · 15 genes
- Notch TGF-β Endothelial · 20 genes
- Vascular Lumen Formation · 8 genes
- ZEB1-driven EMT · 16 genes
Gut residence (1)
- Lymphatic EC Identity · 13 genes
Housekeeping (4)
- Endosomal Vesicle Trafficking · 14 genes
- Glycolytic Housekeeping · 10 genes
- Housekeeping Mixed · 9 genes
- Metabolic Housekeeping · 14 genes
Immune regulation (4)
- Apoptosis Immune Regulation · 11 genes
- Innate Immune Activation · 18 genes
- MHC-I Antigen Presentation · 11 genes
- NF-κB Autophagy Regulation · 12 genes
Inflammation (11)
- Antigen Presentation IFN · 11 genes
- AP-1 Immediate Early · 16 genes
- Genotoxic Innate Inflammation · 10 genes
- IL33 Alarmin Response · 13 genes
- Inflammatory cAMP Response · 8 genes
- NF-κB Inflammatory Activation · 18 genes
- NF-κB Inflammatory Activation · 10 genes
- NF-κB Innate Signaling · 20 genes
- NF-κB Negative Feedback · 13 genes
- TBK1-JAK Immune Signaling · 15 genes
- Type I Interferon · 13 genes
Lipid metabolism (3)
- Fatty Acid Oxidation · 9 genes
- Leukotriene Biosynthesis · 9 genes
- Lipid Metabolic Regulation · 14 genes
migration & adhesion (10)
- Basement Membrane ECM · 13 genes
- Collecting Lymphatic Identity · 22 genes
- DPP4+ Progenitor State · 8 genes
- ECM Remodeling TGFb · 17 genes
- ECM-driven Migration · 11 genes
- Focal Adhesion Migration · 11 genes
- Hippo-Adhesion Signaling · 10 genes
- Integrin Focal Adhesion · 13 genes
- MAPK-ERK Signaling · 15 genes
- Polarized Vesicle Trafficking · 14 genes
Mitochondrial & OxPhos (8)
- GIMAP mediated permeability · 11 genes
- Mitochondrial Cristae Organization · 15 genes
- Mitochondrial OxPhos Complex · 15 genes
- Mitochondrial OxPhos Complex · 14 genes
- Mitochondrial OxPhos Complex · 15 genes
- Mitochondrial Translation · 10 genes
- Oxidative Phosphorylation · 14 genes
- Oxidative Phosphorylation · 12 genes
Protein processing & ER (4)
- 20S Proteasome Core · 13 genes
- ER-Lysosomal Processing · 11 genes
- Proteasome Assembly · 14 genes
- Protein Quality Control · 10 genes
RNA processing & translation (5)
- AhR mRNA Regulation · 12 genes
- mRNA Translation Regulation · 9 genes
- Pre-mRNA Splicing · 15 genes
- RNA Protein Homeostasis · 11 genes
- Translation Elongation · 11 genes
Stress (15)
- DNA Damage Autophagy · 11 genes
- Heat Shock Chaperone · 8 genes
- Heat Shock Response · 12 genes
- Hypoxia HIF Response · 13 genes
- Hypoxia Response · 20 genes
- Hypoxic Stress Response · 8 genes
- Integrated Stress Response · 11 genes
- Integrated Stress Response · 8 genes
- NRF2 Oxidative Stress · 8 genes
- NRF2 Oxidative Stress · 20 genes
- Oxidative Stress Protection · 19 genes
- Oxidative Stress Response · 12 genes
- Oxidative Stress Response · 10 genes
- Stress Granule Assembly · 12 genes
- Stress Kinase Signaling · 15 genes
Valve formation (4)
- Lymphatic Valve Development · 14 genes
- Lymphatic Valve Formation · 14 genes
- Lymphatic Valve Formation · 18 genes
- Lymphatic Valve Identity · 22 genes