PDGFC — Platelet derived growth factor C
PDGFC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDGFC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1 +10 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Receptor Signaling endothelial development | ADGRF5, ART4, ENTREP1, FLRT2, P3H2, PLSCR4, SNCAIP, SRGAP3 +2 more | View in SCUBA |
| Macrophages | Macrophage Migration Migration & adhesion | CEMIP2, CPM, EPB41L2, EPS8, GBE1, ITGA9, KCNQ1, MAN1A1 +12 more | View in SCUBA |
| Smooth muscle cells | FOXF2 Mesenchymal Patterning Development | ADAMTS6, APCDD1, BDKRB2, DCHS1, FAT4, FOXF2, KCNH2, MFAP5 +2 more | View in SCUBA |
About the gene
| Synonyms | fallotein, SCDGF |
|---|---|
| Chromosome | 4: 156760454-156971799 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Growth factor, Mitogen |
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.