FLRT2 — Fibronectin leucine rich transmembrane protein 2
FLRT2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLRT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CMBL, CTDSPL, DDB2, ITM2C, KLHL4 +11 more | View in SCUBA |
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, CENPW, DCLK1, FOXP2, IGFBP4, KIAA0408, MAOB +8 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Receptor Signaling endothelial development | ADGRF5, ART4, ENTREP1, P3H2, PDGFC, PLSCR4, SNCAIP, SRGAP3 +2 more | View in SCUBA |
About the gene
| Chromosome | 14: 85530144-85654428 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Cell adhesion |
Function
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.