SNCAIP — Synuclein alpha interacting protein
SNCAIP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNCAIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | CCDC71L, FABP4, LAPTM5, MAP3K1, MDK, PCBD1, PMVK, RASSF4 +2 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Receptor Signaling endothelial development | ADGRF5, ART4, ENTREP1, FLRT2, P3H2, PDGFC, PLSCR4, SRGAP3 +2 more | View in SCUBA |
About the gene
| Synonyms | SYPH1 |
|---|---|
| Chromosome | 5: 122311354-122464219 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
Function
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.