Endothelial Receptor Signaling
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include PDGFC (PDGF-C ligand, vascular growth factor), TEK (Tie2 angiopoietin receptor, canonical endothelial/lymphatic marker), ADGRF5 (adhesion GPCR, endothelial), FLRT2 (fibronectin leucine-rich repeat, cell adhesion/signaling), SRGAP3 (Slit-Robo GAP, vascular guidance), P3H2 (prolyl 3-hydroxylase, collagen/ECM), PLSCR4 (phospholipid scramblase). TEK and PDGFC are strong endothelial development signals. TEK/Tie2 is critical for lymphatic and blood vessel development. ADGRF5 is expressed in endothelial cells. This module represents endothelial/lymphatic receptor signaling for vascular development.
Genes
ADGRF5, ART4, ENTREP1, FLRT2, P3H2, PDGFC, PLSCR4, SNCAIP, SRGAP3, TEK, TMOD2
Most correlated modules
- Hypoxia Response · correlation 0.91
- Lymphatic Valve Development · correlation 0.88
- Actin Cytoskeletal Scaffold · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.83
- Lipid Metabolic Regulation · correlation 0.83
- Endothelial Identity · correlation 0.77
- Lymphangiogenesis ECM · correlation 0.76
- IL33 Alarmin Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.