ESRRA — Estrogen related receptor alpha
ESRRA belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ESRRA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Fatty Acid Oxidation Mitochondrial & OxPhos | ACADVL, AK3, CAPNS1, ELOVL1, EPB41L4B, ESRP1, FUCA1, GLTP +11 more | View in SCUBA |
About the gene
| Synonyms | ERR1, ERRa, ERRalpha, ESRL1, NR3B1 |
|---|---|
| Chromosome | 11: 64305497-64316743 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Receptor |
| Biological process | Transcription, Transcription regulation |
Function
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.