Fatty Acid Oxidation
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes anchor this module in mitochondrial fatty acid oxidation and intermediary metabolism. HADHB (mitochondrial trifunctional protein beta subunit, long-chain FAO), ACADVL (very long chain acyl-CoA dehydrogenase, FAO), IDH3A (isocitrate dehydrogenase 3 alpha, TCA cycle), PCK2 (mitochondrial PEPCK, gluconeogenesis/cataplerosis), AK3 (adenylate kinase 3, mitochondrial energy sensing), and ESRRA (estrogen-related receptor alpha, master regulator of mitochondrial biogenesis and FAO) form a coherent mitochondrial metabolic program. ELOVL1 (fatty acid elongation), GLTP (glycolipid transfer protein), NFE2L2/NRF2 (oxidative stress master regulator, also regulates FAO), SEPHS2 (selenophosphate synthetase, antioxidant), and CAPNS1 (calpain small subunit) are consistent with colonocyte lipid/energy metabolism. The negative delta_inflammation_CD signal suggests this metabolic program is suppressed in CD-associated inflammation, consistent with known metabolic reprogramming in IBD epithelium.
Genes
Most correlated modules
- Actin-Motor Organization · correlation 0.81
- Ubiquitin-Proteasome System · correlation 0.74
- Fatty Acid Oxidation · correlation 0.73
- Mitochondrial OxPhos · correlation 0.71
- Cellular Senescence · correlation 0.70
- Mitochondrial Maintenance · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.