SCUBA

CAPNS1 — Calpain small subunit 1

CAPNS1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CAPNS1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin Cytoskeleton
Cytoskeletal
ARHGDIB, ARPC3, ATP5MG, GMFG, IFI27L2, OAZ1, SERF2, TAF10 +1 moreView in SCUBA
CD8⁺ T cellsActomyosin Motility
Cytoskeletal
ACTR2, ADGRE5, AP2B1, ARGLU1, EMB, GNAI2, MYH9, PPP1R12A +2 moreView in SCUBA
Gamma-delta T cellsT-bet Effector Differentiation
T cell maturation
ABHD17A, BCL7C, CHST12, DGKZ, EFHD2, FMNL1, GNAI2, GNB2 +15 more
Lymphatic endothelialMetabolic Housekeeping
Housekeeping
CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, ISCU, OCIAD1 +5 moreView in SCUBA
MacrophagesER Protein Processing
Housekeeping
ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 moreView in SCUBA
Mucosal-associated invariant T cellAntigen Processing
Protein processing & ER
AQP3, ATP5MJ, CCDC107, CTDNEP1, NCR3, NSA2, PHB2, PPA1 +8 more
Natural Killer cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
ANXA6, ARPC1B, ARPC4, BAX, CAPZB, GNAI2, IL2RG, NDUFA13 +7 moreView in SCUBA
Smooth muscle cellsAdhesion Activation
Migration & adhesion
ANXA2, ATP1B3, CD44, CYBRD1, FHL2, LAMC1, LGALS3, LGALS3BP +3 moreView in SCUBA

About the gene

Synonyms30K, CANP, CANPS, CAPN4, CDPS
Chromosome19: 36139953-36150353
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins

Function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.