ACADVL — Acyl-CoA dehydrogenase very long chain
ACADVL belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACADVL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | CHMP1A, COX14, EIF2AK1, EML2, ETFA, GPR108, NDUFA8, PARP1 +12 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8, CRELD2 +20 more | |
| Macrophages | ER Protein Translocation Vesicular traficking | ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3, ELOVL1 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | APOL3, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1, PLEKHF1 +4 more |
About the gene
| Synonyms | ACAD6, LCACD, VLCAD |
|---|---|
| Chromosome | 17: 7217125-7225266 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long- chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.