FUCA1 — Alpha-L-fucosidase 1
FUCA1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FUCA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, GEM, GRAMD2B, HMOX1 +14 more | |
| Innate lymphoid cells | RNA Processing Mixed RNA processing & translation | AUP1, B3GAT3, CFDP1, CMTM3, DENR, EIF4H, FBXW5, FYTTD1 +13 more | View in SCUBA |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA5 +30 more | View in SCUBA |
About the gene
| Chromosome | 1: 23845077-23868290 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosidase, Hydrolase |
| Biological process | Lipid metabolism |
Function
Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.