FAN1 — FANCD2 and FANCI associated nuclease 1
FAN1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Damage Response Stress | ACSL4, AKNA, ALDH4A1, ATF7IP, ATM, BAIAP2, BCL11B, BCL9 +22 more | View in SCUBA |
About the gene
| Synonyms | KIAA1018, MTMR15 |
|---|---|
| Chromosome | 15: 30890559-30943108 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Endonuclease, Exonuclease, Hydrolase, Nuclease |
| Biological process | DNA damage, DNA repair |
Function
Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.