FERMT1 — FERM domain containing kindlin 1
FERMT1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FERMT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Inflammatory Stress Response Stress | ANXA3, ANXA5, BCAP29, C4orf3, CD47, CKLF, DNTTIP1, GOLT1B +13 more | View in SCUBA |
About the gene
| Synonyms | C20orf42, FLJ20116, KIND1, UNC112A, URP1 |
|---|---|
| Chromosome | 20: 6074845-6123214 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.