CKLF — Chemokine like factor

CKLF belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CKLF's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Actin Cytoskeleton Cytoskeletal	ABRACL, CAPZB, CD53, CFL1, DRAP1, GUK1, MYL12B, PPIB +6 more	View in SCUBA
Gamma-delta T cells	DNA Repair Housekeeping Housekeeping	ANAPC16, CCDC85B, CDIP1, COTL1, DNAJC4, ECH1, ERCC1, IFT27 +10 more
Goblet cells	Sterol Biosynthesis Housekeeping	ACAT2, COPS9, DHCR24, EBP, FDPS, PLP2, TXNDC17	View in SCUBA
Innate lymphoid cells	Endosomal Trafficking Signaling Immune regulation	ARF1, CCDC85B, COMMD8, FAM50A, GDE1, HAX1, IL27RA, LSM8 +16 more	View in SCUBA
Macrophages	ER Protein Glycosylation Vesicular traficking	AK2, ALG3, ALG5, BABAM1, CRELD2, DDOST, DPM3, FAM136A +21 more	View in SCUBA
Mucosal-associated invariant T cell	Cellular Housekeeping Housekeeping	ABI3, AP2M1, CD151, CD2, DYNLL1, FDFT1, LRP10, NOP10 +7 more
Natural Killer cells	Resident NK program Gut residency	ACP5, CDH17, CHCHD10, ID3, KRT81, KRT86, NEDD9, RGL4 +2 more	View in SCUBA
Neutrophils	Myeloid Identity Housekeeping	ANP32A, CMTM2, HLA-C, HLA-E, IFITM2, ITM2B, LST1, MYL12A +3 more

About the gene

Synonyms	C32, CKLF1, CKLF3, CKLF4, HSPC224, UCK-1
Chromosome	16: 66552563-66566251
Predicted location	Intracellular, Membrane, Secreted
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Molecular function	Cytokine
Biological process	Chemotaxis

Function

May play an important role in inflammation and regeneration of skeletal muscle. Essential for embryonic development (By similarity). Has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.