ANXA5 — Annexin A5
ANXA5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANXA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Housekeeping Metabolic Housekeeping | ATP5MC3, CCT5, COX6B1, CTSL, DCTPP1, ERH, GSTO1, NDUFB7 +8 more | View in SCUBA |
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ARF1, ATP6AP2, MORF4L1, MTDH, OCIAD1, PTGES3, RAB2A, SELENOF +6 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Response Stress | ATP6V0B, CCT3, CD59, DRAP1, EIF5A, GPX4, NUPR1, PDLIM4 +3 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC, ENO1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | AKR7A2, ANP32A, AP1M1, APEX1, APOBEC3C, CDC26, DBNL, DCK +17 more | |
| Smooth muscle cells | Proteasome And Translation Protein processing & ER | EIF2S2, EIF4A1, ENO1, MORF4L1, PSMA4, PSMB3, PSME1, RBM3 +2 more | View in SCUBA |
About the gene
| Synonyms | ANX5, CPB-I, ENX2, PAP-I, RPRGL3, VAC-alph |
|---|---|
| Chromosome | 4: 121667946-121696995 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Blood coagulation, Hemostasis |
Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.