FOXJ1 — Forkhead box J1
FOXJ1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FOXJ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Differentiation Granulocyte development | ACSL4, ALOX5AP, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, HDC +6 more |
About the gene
| Synonyms | FKHL13, HFH-4, HFH4 |
|---|---|
| Chromosome | 17: 76136333-76141245 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cilium biogenesis/degradation, Transcription, Transcription regulation |
Function
Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.