BACE2 — Beta-secretase 2
BACE2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BACE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | p53 Stress Response Stress | COPS9, NT5C, OST4, PDLIM1, PGLS, POLR2L, RFXANK, SEM1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Differentiation Granulocyte development | ACSL4, ALOX5AP, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1, HDC +6 more |
About the gene
| Synonyms | AEPLC, ALP56, CEAP1, DRAP |
|---|---|
| Chromosome | 21: 41167801-41282530 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Aspartyl protease, Hydrolase, Protease |
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.