ALOX5AP — Arachidonate 5-lipoxygenase activating protein

ALOX5AP belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ALOX5AP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Naive B-cell identity B cell maturation	CD79B, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SEC62, SIAH2 +7 more	View in SCUBA
CD4⁺ T cells	Cytotoxic effector Cytotoxicity	ADAP1, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2, DOCK5 +15 more	View in SCUBA
CD8⁺ T cells	Gut Tissue Residency Gut residence	C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3, ID2 +9 more	View in SCUBA
Hematopoietic progenitor cells	Mast Cell Differentiation Granulocyte development	ACSL4, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1, HDC +6 more
Innate lymphoid cells	ILC1 Inflammatory Activation Inflammation	CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32, LPXN +11 more	View in SCUBA
Monocytes	Leukotriene-Alarmin Response Inflammatory	CDA, METTL9, MTARC1, PLBD1, QPCT, RFLNB, S100A12, TMEM38A	View in SCUBA
Natural Killer cells	NK Cytotoxic Activation Cytotoxicity	ABI3, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, HCLS1, LAT2 +3 more	View in SCUBA
Neutrophils	Mature Neutrophil Activation Innate immunity	AIF1, C4orf3, CD14, MCEMP1, PRELID1, SLC2A3, TIMP1, TYMP +1 more

About the gene

Synonyms	FLAP
Chromosome	13: 30713478-30764426
Predicted location	Membrane
Essential gene	No
Protein class	Disease related genes, Predicted membrane proteins
Biological process	Leukotriene biosynthesis

Function

Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.