FPGS — Folylpolyglutamate synthase
FPGS belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FPGS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ACAP1, ANTKMT, ATP6V0E2, B3GAT3, CCDC57, CHN2, CMTM3, DCTD +12 more | |
| Monocytes | Endosomal Sorting Vesicular traficking | GAB2, GGA2, HGS, MAFG, PIK3R5, SEMA6B, SSH1, TPRA1 +1 more | View in SCUBA |
About the gene
| Chromosome | 9: 127794597-127814327 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | One-carbon metabolism |
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.