B3GAT3 — Beta-1,3-glucuronyltransferase 3
B3GAT3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
B3GAT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ACAP1, ANTKMT, ATP6V0E2, CCDC57, CHN2, CMTM3, DCTD, DGUOK +12 more | |
| Innate lymphoid cells | RNA Processing Mixed RNA processing & translation | AUP1, CFDP1, CMTM3, DENR, EIF4H, FBXW5, FUCA1, FYTTD1 +13 more | View in SCUBA |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46, DNAJA2 +23 more | View in SCUBA |
About the gene
| Synonyms | GlcAT-I |
|---|---|
| Chromosome | 11: 62615296-62622154 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
Function
Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate- glucuronic acid (UDP-GlcUA) during completion of linkage region formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.