Metabolic Housekeeping
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include FPGS (folate metabolism), DGUOK (mitochondrial nucleotide salvage), NDUFV1 (complex I subunit), DNAJC15 (mitochondrial chaperone), ECHDC2 (mitochondrial fatty acid metabolism), ANTKMT (mitochondrial methyltransferase), ATP6V0E2 (vacuolar ATPase). The module combines mitochondrial metabolic enzymes and general housekeeping metabolic functions. Uniform expression across all subsets with moderate pct positive supports a constitutive housekeeping metabolic program rather than a cell-state-specific response.
Genes
ACAP1, ANTKMT, ATP6V0E2, B3GAT3, CCDC57, CHN2, CMTM3, DCTD, DGUOK, DNAJC15, ECHDC2, FPGS, NDUFV1, NICOL1, OCIAD1, PDCD2, SCCPDH, SWI5, TRMT2A, TSNAX, ZNF780A
Most correlated modules
- Ubiquitin-Proteasome Trafficking · correlation 0.85
- DNA Repair Housekeeping · correlation 0.83
- DNA Damage Repair · correlation 0.83
- Actin-based Motility · correlation 0.82
- RNA Splicing Nuclear · correlation 0.81
- Mitochondrial Dynamics · correlation 0.80
- Mitochondrial Ribosome · correlation 0.79
- Mitochondrial Housekeeping · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.