ACAP1 — ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACAP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B, GATAD1 +7 more | View in SCUBA |
| CD8⁺ T cells | TCR Complex Signaling TCR Signaling | ANXA1, CD37, CD3E, CITED2, DUSP1, EVL, LAPTM5, LCK +4 more | View in SCUBA |
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ANTKMT, ATP6V0E2, B3GAT3, CCDC57, CHN2, CMTM3, DCTD, DGUOK +12 more | |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK, MFGE8 +14 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3, FLOT2 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signaling Identity TCR Signaling | CASP4, CD3G, CENPT, CFAP97, DPP7, FBXW5, IL27RA, LMF2 +10 more | |
| Natural Killer cells | NK Homeostatic Survival Immune regulation | ARHGAP30, CAPN12, FYB1, GIMAP6, GPR174, IRF2, SLFN5, STOM +1 more | View in SCUBA |
About the gene
| Synonyms | CENTB1, KIAA0050 |
|---|---|
| Chromosome | 17: 7336529-7351477 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
| Biological process | Protein transport, Transport |
Function
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.