GABRA4 — Gamma-aminobutyric acid type A receptor subunit alpha4
GABRA4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GABRA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Actomyosin Regulation Contractility | ARID5A, ASAH1, CAP2, COX6A2, DMTN, HAPLN2, NAPA, NMRK2 +6 more | View in SCUBA |
About the gene
| Chromosome | 4: 46918900-46993581 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins |
| Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Function
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3- delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.