Actomyosin Regulation
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Core members regulate the actomyosin apparatus: PPP1R12A (MYPT1, myosin phosphatase targeting subunit central to SMC Ca2+-sensitization), DMTN (dematin actin-bundling), CAP2 (actin depolymerization/ capping), plus muscle-specific metabolic genes NMRK2 and COX6A2 and the vesicle/trafficking components NAPA, SORT1, OSBPL9, RALBP1, ASAH1. The mixed membership scores of the trafficking genes suggest a dominant contractile-regulation program with a peripheral vesicular/lipid arm; consistent with neighbors M36/M109 that describe contractile, oxidative SMC states.
Genes
ARID5A, ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA, NMRK2, OSBPL9, PPP1R12A, RALBP1, RGCC, SORT1, TSPAN13
Most correlated modules
- Wnt-Notch Modulation · correlation 0.87
- Vascular SMC Identity · correlation 0.86
- Oxidative Muscle Metabolism · correlation 0.84
- Muscle Energy Metabolism · correlation 0.83
- Myogenic Cytoskeletal Program · correlation 0.80
- Mural/Pericyte Identity · correlation 0.76
- Pericyte Signature · correlation 0.75
- Cytoskeletal trafficking kinases · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.