ARID5A — AT-rich interaction domain 5A
ARID5A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARID5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1, HLA-DQA1 +9 more | View in SCUBA |
| CD4⁺ T cells | IL6-STAT3 Signaling Intercellular communication | ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D, EIF4G2 +13 more | View in SCUBA |
| Endothelial | Notch Arterial Identity Endothelial cell development | ADAMTS1, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2, GADD45A +14 more | View in SCUBA |
| Glial cells | COX-2/NF-κB Inflammation Inflammation | ABL2, BCL3, EMP1, LMNA, PDLIM3, PHLDA1, PTGS2 | View in SCUBA |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1, IFIH1 +29 more | View in SCUBA |
| Monocytes | Fc Receptor Activation Innate immunity | CD300E, CREM, FCGR2A, GLUL, LCP2, OLR1, PLSCR1, TRIM25 | View in SCUBA |
| Smooth muscle cells | Actomyosin Regulation Contractility | ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA, NMRK2 +6 more | View in SCUBA |
About the gene
| Synonyms | MRF-1, RP11-363D14 |
|---|---|
| Chromosome | 2: 96536743-96552634 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor, RNA-binding |
| Biological process | Immunity, Innate immunity, Transcription, Transcription regulation |
Function
DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May positively regulate chondrocyte- specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1- mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As an RNA- binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.