NMRK2 — Nicotinamide riboside kinase 2
NMRK2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NMRK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Actomyosin Regulation Contractility | ARID5A, ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA +6 more | View in SCUBA |
About the gene
| Synonyms | ITGB1BP3, MIBP, NRK2 |
|---|---|
| Chromosome | 19: 3933069-3942416 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Pyridine nucleotide biosynthesis |
Function
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.