GTF2E2 — General transcription factor IIE subunit 2
GTF2E2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF2E2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, IKBKE, LYSET +20 more | View in SCUBA |
About the gene
| Synonyms | FE, TF2E2, TFIIE-B |
|---|---|
| Chromosome | 8: 30578318-30658236 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.